Anti-HIV
Eleven products containing PVP-Iodine were tested for their ability to inactivate human immunodeficiency virus (HIV) in a cell culture system. All of the products completely inactivated the virus at PVP-Iodine concentrations greater than 0.5% except for the lubricating antiseptic gel, which required 2.5%. Douche and medicated douche products did not inactivate HIV at the concentrations prescribed for usual clinical use (0.33% and 0.25%, respectively) but were effective at PVP-Iodine concentration of 0.5%.
In Vivo Studies
Numerous in vivo studies made over approximately 35 years, as well as the widespread clinical use of products containing PVP-Iodine, indicate the efficacy of 'PVP-Iodine as a therapeutic agent for both humans and animals. Following are some of the published papers supporting the clinical effectiveness of PVP-Iodine.
Treatment of Wounds
PVP-Iodine Topical Solution (10% PVP-Iodine containing 1.0% available iodine) is effective for ridding and preventing infections, including those with severe
ulceration.
Scrub and Skin Disinfection
PVP-Iodine Surgical Scrub is a 7.5% PVP-Iodine solution (0.75% available iodine) containing various agents for wound and skin cleansing. It should be rinsed off immediately after use to minimize skin irritation and healing retardation.
To reduce germs on skin and prevent infections in skin, the PVP-Iodine Topical Solution containing 10% PVP-Iodine (1% available iodine) should be used. The PVP- Iodine film should remain on the skin so that it can act as a continued antimicrobial barrier.
To measure the efficacy of surgical scrubs, samples of scrub juices were taken to establish immediate, cumulative and persistent effects. The immediate effect is the reduction of bacteria found immediately after scrubbing: A cumulative effect is seen when regular use of the scrub leads to increasing reductions of bacteria. The final measurement, persistence of effect, is defined as a decline in the post wash bacterial count. Studies with PVP-Iodine scrubs showed an effective, extensive immediate effect, a definite cumulative effect, and a persistence of effect17-20 |
