PVP-Iodine, Povidone-Iodine, was introduced to the pharmaceutical market as an antiseptic agent in the fifties and is as effective as iodine itself against a broad spectrum of disease causing microorganisms. It differs from iodine in that it is less irritating to the skin and does not require iodides or alcohol to dissolve. Additionally, PVP-Iodine stains are water washable. Early promotional materials refer to PVP-Iodine as "tamed iodine" because of its safety. Furthermore, the poison label required for iodine products is not necessary in commercial preparations containing PVP-Iodine.

PVP-Iodine is used in both human and veterinary medicine to kill on contact a wide variety of bacteria, viruses, fungi, protozoa, and yeasts. It has also been shown to be effective in controlling some insects. There has been no reported microbial resistance to PVP-Iodine.

At the same time, PVP-Iodine is safer and easier to use than classic iodine preparations and has low systemic toxicity. Unlike iodine solutions, it is nonsensitizing and does not cause pain when applied to wounds or mucous membranes. PVP-Iodine forms films that protect open wounds. These films can be washed in water and will not permanently stain skin, natural fibers or hard surfaces. It is exceptionally easy to use because it is soluble in water as well as in organic solvents, such as alcohols. PVP-Iodine can be used in powders, tablets, solutions, lotions, ointments, creams or sprays.

The prolonged non-selective anti-microbial action of PVP-Iodine is unparalleled for surface microbiocidal activity and particularly effective in treating mixed infections.Its effectiveness has been clinically proven for all types of topical applications in both human and veterinary medicine.